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KMID : 0367320130240030151
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Journal of the Korean Academy of Child and Adolescent Psychiatry
2013 Volume.24 No. 3 p.151 ~ p.156
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D8/17 Expression on B Lymphocytes of Children and Adolescents with Tic Disorder
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Oh Yung-Gun
Park Tae-Won
Jung Yong-Woo
Chung Sang-Keun
Chung Young-Chul
Yang Jong-Chul
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Abstract
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Objectives : It has been reported that higher percentage of B cells react with monoclonal D8/17 antibody in patients with rheumatic fever, childhood onset obsessive-compulsive disorder, Tourette’s disorder, or prepubertal anorexia nervosa. The purpose of this study is to replicate the previous studies in a Korean young population with tic disorder and to identify any relationship between D8/17 and clinical symptoms.
Methods : The binding of D8/17 to B cells was determined in patients with tic disorder (N=21) and healthy controls (N=9) by Fluorescence-Activated Cell Sorter analysis.
Results : In the sample examined by this study, the average percentage of B cells expressing D8/17 in tic disorder was 2.05%; healthy controls was 3.15%. No statistically significant differences were found in the mean percentages of D8/17 between the two groups.
Conclusion : The expression of D8/17 in B cells was very low in this study. No subjects with tic disorder or healthy controls was above 12% in D8/17 positive proportion. Further studies, including higher number of patients and control group members, should be performed.
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KEYWORD
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Tic Disorder, D8/17, ASO, PANDAS, FACS
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